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ID 105
file
creator
Cirelli, J.A.
Giannobile, William V.
subject
gene therapy
growth factors
tissue engineering
periodontal regeneration
regenerative medicine
NDC
Medical sciences
abstract
Although significant advancements have been achieved in periodontal therapy over the last decade, predictable regeneration of the tooth-supporting tissues is a challenge in periodontology and oral implantology. Recently, gene therapy, a new therapeutic approach for genetic and acquired diseases, has been applied for tissue bioengineering in multiple clinical situations, including the craniofacial complex, among them defects resulting from periodontal disease. The use of gene therapy vectors has enhanced the bioavailability and targeting of multiple growth and host immune factors to repair alveolar bone defects. Early pre-clinical studies utilizing both ex vivo and in vivo gene transfer strategies demonstrate the feasibility of using gene therapy for periodontal tissue engineering. This review highlights the current progress made in the field of periodontal regenerative medicine via gene targeting approaches.
journal title
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
start page
120
end page
125
date of issued
2006-01-08
language
eng
nii type
Conference Paper
HU type
Conference Papers
DCMI type
text
format
application/pdf
text version
publisher
relation is part of URL
http://ir.lib.hiroshima-u.ac.jp/00014842
department
Graduate School of Biomedical Science