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ID 39063
file
creator
Karki, Prasanna
Hirano, Hirofumi
Yamahata, Hitoshi
Fujio, Shingo
Yonezawa, Hajime
Bohara, Manoj
Oyoshi, Tatsuki
Hanaya, Ryosuke
Arita, Kazunori
subject
Langerhans cell histiocytosis
Skull
Immunostaining
Histology
NDC
Medical sciences
abstract
Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may manifest as a unisystem (unifocal or multifocal) or multisystem disease. We describe the clinical and histologic spectrum of LCH of the orbit and skull in our two cases. Both cases had unifocal erosive skull lesions with a history of trauma. Typical histologic features included numerous histiocytes with varying degrees of giant cell formation and scattered eosinophilic granulocytes. The presence of Langerhans cells was confirmed by CD1a and S100 immunohistochemistry. LCH has an excellent prognosis when treated with surgical resection, steroids and radiotherapy or chemotherapy. One of our patients is disease free at 7 year follow-up and one patient had regression of lesion on follow-up.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 64
issue
Issue 4
start page
59
end page
63
date of issued
2015-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Hiroshima University Medical Press
department
Graduate School of Biomedical & Health Sciences
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