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ID 45927
file
creator
Shimada, Hiroyuki
Kada, Akiko
Shima, Haruko
Tono, Chikako
Yuza, Yuki
Kurosawa, Hidemitsu
Watanabe, Akihiro
Ito, Masaki
Uryu, Hideko
Kamibeppu, Kiyoko
Kiyokawa, Nobutaka
Adachi, Souichi
Saito, Akiko M.
Tanizawa, Akihiko
subject
chronic myeloid leukaemia
children
tyrosine kinase inhibitors
NDC
Medical sciences
abstract
Chronic myeloid leukaemia (CML) is a relatively rare disease in children, accounting for 2–3% of all paediatric leukaemia cases. Generally, children with CML can avoid hematopoietic stem cell transplantation and achieve molecular responses with tyrosine kinase inhibitors (TKI). However, CML stem cells are thought to survive in many patients, even after TKI treatment. Many aspects of the toxic effects of prolonged exposure to TKIs during childhood remain unclear, particularly those regarding growth impairment. This lack of clarity underscores the importance of the present clinical trial, which aims to clarify the feasibility of treatment-free remission (TFR) in children following TKI treatment. We aim to examine the long-term out-comes and complications of TKIs before and after cessation to better understand the unknown complications that could arise in adulthood. This trial targets patients who were diagnosed with CML at an age younger than 20 years, were in the chronic or accelerated phase at initial diagnosis and remained in complete molecular remission for at least 2 years after TKI administration. We will examine the utility of TKI cessation and assess the treatment results of patients who resumed TKI therapy after losing a major molecular response. We will also investigate factors related to the feasibility of a TFR after TKI cessation.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 67
issue
Issue 1
start page
7
end page
13
date of issued
2018-03
publisher
Hiroshima University Medical Press
issn
0018-2052
2433-7668
ncid
publisher doi
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2018 Hiroshima University Medical Press
relation url
department
Graduate School of Biomedical & Health Sciences
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