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ID 30412
file
creator
Shimomura, Manabu
Takakura, Yuji
Kawaguchi, Yasuo
Tokunaga, Masakazu
Takeda, Haruka
Sumitani, Daisuke
Yoshimitsu, Masanori
Okajima, Masazumi
subject
Gastrointestinal stromal tumor
Small intestine
Pediatric populations
The c-kit gene mutation
NDC
Medical sciences
abstract
An 18-year-old girl presented with abdominal pain and a tumor was subsequently detected in the jejunum. We therefore carried out a wedge resection of the jejunum. The diagnosis of GIST was confirmed histologically, and a mutation in exon 9 of the c-kit gene was observed. GISTs are rare in pediatric populations and pediatric GISTs occur predominantly in females and are characterized by a multifocal gastric location and a wild-type phenotype for the c-kit genes. The features of pediatric GISTs of the small intestine have not yet been categorized, and to date, only 11 cases in patients younger than 18 years have been reported. These cases did not occur primarily in females and tended to present as single tumors with mutations in the c-kit gene. This suggests that these cases do not have the same features as pediatric gastric GISTs, but instead are similar to adult GISTs.
journal title
Pediatric Surgery International
volume
Volume 26
issue
Issue 6
start page
649
end page
654
date of issued
2010
publisher
Springer
issn
0179-0358
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) Springer-Verlag 2010
relation
The original publication is available at www.springerlink.com
relation url
department
Graduate School of Biomedical Science