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ID 27771
file
creator
Tamaki, Masako
Matsuoka, Tatsuya
Hori, Tadao
subject
Sleep
Memory
Learning
Sleep spindle
Fast spindle
Premotor cortex
Parietal associative area
NDC
Medical sciences
abstract
Objective: The present study examined whether slow and/or fast sleep spindles are related to visuomotor learning, by examining the densities of current sleep spindle activities. Methods: Participants completed a visuomotor task before and after sleep on the learning night. This task was not performed on the non-learning night. Standard polysomnographic recordings were made. After the amplitudes of slow and fast spindles were calculated, sLORETA was used to localize the source of slow and fast spindles and to investigate the relationship between spindle activity and motor learning. Results: Fast spindle amplitude was significantly larger on the learning than on the non-learning nights, particularly at the left frontal area. sLORETA revealed that fast spindle activities in the left frontal and left parietal areas were enhanced when a new visuomotor skill was learned. There were no significant learning-dependent changes in slow spindle activity. Conclusions: Fast spindle activity increases in cortical areas that are involved in learning a new visuomotor skill. The thalamocortical network that underlies the generation of fast spindles may contribute to the synaptic plasticity that occurs during sleep. Significance: Activity of fast sleep spindles is a possible biomarker of memory deficits.
journal title
Clinical Neurophysiology
volume
Volume 120
issue
Issue 5
start page
878
end page
886
date of issued
2009
publisher
Elsevier Ireland Ltd
issn
1388-2457
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2009 International Federation of Clinical Neurophysiology Published by Elsevier Ireland Ltd.
relation url
department
Graduate School of Integrated Arts and Sciences