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ID 37664
file
creator
Kumagai, Hajime
Sugawara, Yuji
Isaka, Mitsuhiro
Okada, Kenji
Orihashi, Kazumasa
subject
Spinal cord ischemia
Cold saline injection
Motor-evoked potential
Thoracoabdominal aortic surgery
NDC
Medical sciences
abstract
Changes in the motor-evoked potential of the spinal cord with transcranial stimulation are monitored for spinal cord function during thoracoabdominal aortic aneurysm surgeries. We examined the effects of changes in motor-evoked potential with cold saline injected into the clamped segment of the aorta, and compared the effects to lidocaine and warm saline injection.  

Eighteen dogs were divided into three groups according to the injected agents: Warm saline group (37°C, 20 ml), Cold saline group (4°C, 20 ml), and Lidocaine group (5.0 mg/kg oflidocaine in 20 ml of warm saline), (n=6, each group). Changes in the peak-to-peak MEP amplitude and the indirect wave (I wave) amplitude were measured during aortic cross-clamping.  

In the peak-to-peak MEP amplitude, the cold saline and lidocaine groups attenuated to 80% of the control value but were not significantly changed. In the I wave amplitude, the cold saline group showed a significant attenuation 1 min after injection (p<0.0001) and the lidocaine group 4 min after injection (p=0.0230), when compared with the warm saline group. Attenuation of the I wave amplitude in the cold saline group was significantly larger than that in the lidocaine group (p=0.0003).  

Changes in the I wave amplitude appeared within 4 min in both the cold saline and lidocaine groups. Cold saline injection into the clamped segment of the aorta is a diagnostic procedure for determining presiding critical arteries in the segment without experiencing the pharmacological side effects observed with lidocaine injection.
description
This work was supported by a Grant-in-aid from the Japanese Ministry of Education, Science and Culture.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 54
issue
Issue 3
start page
77
end page
82
date of issued
2005-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Hiroshima University Medical Press
department
Graduate School of Biomedical Science
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