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ID 25933
file
creator
Uemura, Kenichiro
Hayashidani, Yasuo
Shimamoto, Fumio
subject
ampullary carcinoma
prognostic factor
perineural invasion
pancreatoduodenectomy
NDC
Medical sciences
abstract
Purpose: The aim of this study was to identify prognostic factors in patients undergoing pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma.

Methods: The records of 46 consecutive patients with ampullary carcinoma who underwent pancreatoduodenectomy from 1988 through 2006 were retrospectively reviewed.

Results: A 98% rate of potentially curative (R0) resection was achieved. There was no 30-day mortality. Overall 5-year survival rate was 64%.0 Univariate analysis revealed that T3 and T4 tumor (ie, pancreatic parenchymal invasion) (P<0.001), lymph node metastasis (P=0.01), and perineural invasion (P<0.001) were significant predictors of poor prognosis. Furthermore, perineural invasion was found to be a significant independent predictor of poor prognosis by multivariate analysis (P=0.024).

Conclusions: Pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma is a safe surgical procedure with an acceptable cure rate. The presence of perineural invasion may be useful for predicting poor prognosis in patients with ampullary carcinoma who undergo potentially curative resection.
journal title
Digestive Diseases and Sciences
volume
Volume 53
issue
Issue 8
start page
2281
end page
2286
date of issued
2008-08
publisher
Springer Netherlands
issn
0163-2116
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2008 Springer
relation
The original publication is available at www.springerlink.com
relation url
department
Graduate School of Biomedical Science