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ID 20785
file
creator
Yano, Masatsugu
Hamatani, Kiyohiro
Eguchi, Hidetaka
Hirai, Yuko
MacPhee, Donald G.
Sugino, Keizo
Dohi, Kiyohiko
Itamoto, Toshiyuki
subject
p53 gene
hMSH2 gene
Hepatocellular carcinoma
Intrahepatic metastasis
Multicentric occurrence
NDC
Medical sciences
abstract
Association of gene alterations and prognosis has not fully been elucidated in hepatocellular carcinoma (HCC). To clarify the relationship between p53 and hMSH2 mutations and prognosis, we analysed these mutations in 83 HCC cases and assessed their association with various clinicopathological factors. The 3-year disease-free survival (DFS) or overall survival (OS) rates in HCC patients with p53 mutation and p53 wild/hMSH2 mutation significantly decreased compared with those without these mutations (14.3-0x1.f824p+0nd 37.5% versus 67.5-0.000000or DFS; 35.7-0x1.f5cf80852f11p+0nd 50.0% versus 96.4-0.000000or OS, respectively). In the multivariate analysis, categories by p53 and hMSH2 mutation status, and liver cirrhosis demonstrated statistical significances for DFS and OS. Moreover, the frequency of patients with p53 and/or hMSH2 mutations in intrahepatic metastasis (75.0%) was significantly higher than that in multicentric occurrence (14.3%). Thus, p53 and hMSH2 mutations will be useful for identifying subsets of HCC patients with poor prognosis.
journal title
European Journal of Cancer
volume
Volume 43
issue
Issue 6
start page
1092
end page
1100
date of issued
2007-04
publisher
Elsevier Ltd
issn
0959-8049
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2007 Elsevier Ltd
relation is version of URL
http://dx.doi.org/10.1016/j.ejca.2007.01.032
department
Graduate School of Biomedical Science