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ID 20740
file
creator
Ide, Kentaro
Tahara, Hiroyuki
Ishiyama, Kohei
Shishida, Masayuki
Irei, Toshimitsu
Itamoto, Toshiyuki
subject
cholesterol
living donor liver transplantation
neurotoxicity
soybean oil
NDC
Medical sciences
abstract
Neurotoxicity represents a serious complication following liver transplantation and may be evoked by various perioperative factors or develop due to toxicity of immunosuppresion. The symptoms of neurotoxicity associated with calcineurin inhibitors (CNIs) may be reversed by discontinuing or reducing the dose of CNIs; however, this may increase the risk of rejection. To address this issue, we examined 45 adult living donor liver transplant recipients. At the time of neurotoxicity diagnosis, serum cholesterol values were significantly lower in the patients with neurotoxicity than in those without neurotoxicity. Based on our hypothesis that lipid supplementation prevents lipophilic CNIs from crossing the blood-brain barrier, soybean oil was administered to 5 patients with neurotoxicity. In all these patients, the neurological symptoms improved without discontinuing or reducing the dose of CNIs. This use of this therapy may help in avoiding insufficient immunosuppressive therapy because neither dose reduction nor substitution of CNIs would be then required.
journal title
Transplant International
volume
Volume 20
issue
Issue 7
start page
632
end page
635
date of issued
2007-07
publisher
Blackwell Publishing
issn
0934-0874
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com
relation url
department
Graduate School of Biomedical Science