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ID 28528
file
title alternative
ラット脊髄の圧迫後における神経細胞損失の経過と範囲
creator
Takemoto, Hidenori
Yoshimura, Osamu
Moriyama, Hideki
Imagita, Hidetaka
Shirahama, Kunji
Kajihara, Hiroki
Tobimatsu, Yoshiko
subject
neuronal loss
spinal cord compression
rat
NDC
Medical sciences
abstract
Motor deficits after spinal cord injury arise from damages to the descending spinal pathways and ventral motoneurons (VMN). In contrast to data on damages to the white matter or the descending spinal pathways, few quantitative data on damages to VMN after injury are available currently. The purpose of this study was to examine quantitatively the temporal and spatial pattern of VMN loss after spinal cord compression. Two groups of adult female Wistar rats were used in this study: rats which were subjected to spinal cord compression in short duration with an aneurysm clip (experimental group) and rats which were subjected to a sham-operation (control group). Using serial cross-sections of the spinal cord, VMN were counted up to the 7th day after surgical intervention at 0, 1, 2, and 3 mm rostral and caudal to the lesion epicenter (experimental group) or to the median of the serial sections (control group). At 15 minutes after the compression, VMN were lost only at the epicenter section and no VMN were observed there. By 8 hours, VMN loss had spread to next 1 mm rostral and caudal section to the epicenter. Virtually, no further loss was detected between 8 hours and later time points. This study showed that compression to the adult rat spinal cord in short duration led to VMN loss, which progressed acutely and expanded modestly. Our findings could be used to develop effective treatment and provide a better understanding of VMN loss after spinal cord injury.
journal title
Journal of health sciences, Hiroshima University
volume
Volume 6
issue
Issue 2
start page
111
end page
117
date of issued
2007-09-28
publisher
広島大学保健学出版会
issn
1347-7323
ncid
SelfDOI
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Health Science
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