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ID 17114
file
creator
Minakata, Hiroyuki
Takeshige, K.
Takata, T.
Matsushima, Osamu
Mukai, S.T.
Saleuddin, A.S.M.
Horiguchi, Toshihiro
subject
HPLC
purification
reproduction
imposex
organotin
NDC
Biology
abstract
The GGNG peptides are excitatory neuropeptides identified from earthworms, leeches and polychaeta. Two structurally related peptides were purified and characterized from a mollusk, Thais clavigera (prosobranch gastropod). The peptides designated as TEP-1 (Thais excitatory peptide-1) (KCSGKWAIHACWGGN-NH2) and TEP-2 (KCYGKWAMHACWGGN-NH2) are pentadecapeptides having one disulfide bond and C-terminal GGN-NH2 structures, which are shared by most GGNG peptides. TEP augmented the motilities of Thais esophagus and penial complex. TEP-like immunoreactivity is distributed in both the neurons of the central nervous system and nerve endings in the penial complex. Thus, the involvement of TEP in the contraction of the digestive and reproductive systems is suggested. Substitution of amino acids in TEP revealed that two tryptophan residues in TEP are important for maintaining bioactivity.
journal title
Peptides
volume
Volume 27
issue
Issue 3
start page
483
end page
492
date of issued
2006-03
publisher
Elsevier
issn
0196-9781
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2006 Elsevier Ltd.
relation is version of URL
http://dx.doi.org/10.1016/j.peptides.2005.06.026
department
Graduate School of Science