このエントリーをはてなブックマークに追加
ID 17689
file
creator
Arita, Kazunori
Eguchi, Kuniki
Yoshioka, Hiroyuki
Kanou, Yukari
subject
Vascular endothelial growth factor
Pituitary adenoma
Hemorrhage
NDC
Medical sciences
abstract
The authors investigated the relationship between hemorrhage and the expression of vascular endothelial growth factor (VEGF) in pituitary adenomas. The subjects were 39 patients with pituitary adenomas. Surgically obtained tumor tissue was immunohistochemically stained using antibodies against VEGF, CD-34, Ki-67, and anterior pituitary hormones. The expression of VEGF was graded as 0, 1+, and 2+. The relationship between intratumoral hemorrhage and factors such as tumor size, Ki-67 labeling indices, number of CD-34 positive vessels, and VEGF expression was examined by multivariate analysis. High-grade VEGF expression was the sole independent factor correlated with intratumoral hemorrhage. The number of CD-34 positive vessels had no effect on the incidence of hemorrhage in patients with pituitary adenomas. In conclusion, a positive relationship between VEGF expression and hemorrhage in pituitary adenoma was observed. The patho-mechanical significance of this correlation is under investigation.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 53
issue
Issue 2
start page
23
end page
27
date of issued
2004-06
publisher
Hiroshima University Medical Press
国立情報学研究所
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧