Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00047061
ID | 47061 |
file | |
creator |
Ishida, Keishi
Saiki, Takashi
Umeda, Kanae
Miyara, Masatsugu
|
subject | tributyltin
glutamate receptor 2
developmental neurotoxicity
|
NDC |
Medical sciences
|
abstract | Tributyltin (TBT), a common environmental contaminant, is widely used as an antifouling agent in paint. We previously reported that exposure of primary cortical neurons to TBT in vitro decreased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit glutamate receptor 2 (GluR2) expression and subsequently increased neuronal vulnerability to glutamate. Therefore, to identify whether GluR2 expression also decreases after TBT exposure in vivo, we evaluated the changes in GluR2 expression in the mouse brain after prenatal or postnatal exposure to 10 and 25 ppm TBT through pellet diets. Although the mean feed intake and body weight did not decrease in TBT-exposed mice compared with that in control mice, GluR2 expression in the cerebral cortex and hippocampus decreased after TBT exposure during the prenatal period. These results indicate that a decrease in neuronal GluR2 may be involved in TBT-induced neurotoxicity, especially during the fetal period.
|
description | This study was supported by JSPS KAKENHI (B) Grant Numbers 23310047 (to Y.K.), 15H02826 (to Y.K.), and a Grant-in-Aid for JSPS Fellows Number 14J06534 (to K.I.).
|
journal title |
Biological and Pharmaceutical Bulletin
|
volume | Volume 40
|
issue | Issue 7
|
start page | 1121
|
end page | 1124
|
date of issued | 2017-07-01
|
publisher | The Pharmaceutical Society of Japan
|
issn | 0918-6158
1347-5215
|
ncid | |
publisher doi | |
language |
eng
|
nii type |
Journal Article
|
HU type |
Journal Articles
|
DCMI type | text
|
format | application/pdf
|
text version | publisher
|
rights | © 2017 The Pharmaceutical Society of Japan
|
relation url | |
department |
Graduate School of Biomedical & Health Sciences
|