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ID 51388
file
creator
SAGAWA, Maiko
FUJIWARA, Hisaya
URABE, Rie
NISHIDA, Toshihiro
KATSUBE, Yasuhiro
subject
retroperitoneal cyst
histogenesis
immunohistochemical analysis
mucinous metaplasia
abstract
Primary retroperitoneal cystic lesions (PRCLs) are extremely rare, and their histogenesis and clinical evolution remain unclear. Here, we report the case of a 38-years-old primigravida who was referred to our hospital for the delivery. Routine ultrasonographic examination at 36 weeks of gestation revealed the presence of a cystic mass close to the right side of the uterus. One month after the childbirth, we performed the surgery. The cystic mass was present on the right side of the retroperitoneal cavity. We successfully extracted the cyst without rupture. The cyst was 12 × 6 × 3 cm, unilocular, exhibited a thin wall, and contained mucinous liquid. Histological examination revealed that the lining of the cyst comprised two types of adjacent cells. The flat low cuboidal cells were positive for calretinin, cytokeratin (CK) 5/6, CK7, cancer antigen 125 (CA125), and D2-40, all of which are mesothelial markers. The tall columnar cells were also positive for the mesothelial marker CK7. However, the flat low cuboidal cells were negative for mucinous cell makers, while tall columnar cells were positive for these markers. The tall columnar cells contained mucin but were not positive for gastrointestinal epithelial-specific secreted mucin makers. This finding directly supports our hypothesis that the retroperitoneal cysts emerged from the mesothelium.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 70
issue
Issue 1
start page
17
end page
21
date of issued
2021-06-30
publisher
Hiroshima University Medical Press
issn
0018-2052
2433-7668
ncid
publisher doi
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2021 Hiroshima University Medical Press
relation url
department
Graduate School of Biomedical & Health Sciences
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