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ID 51387
file
creator
KITAHARA, Yoshihiro
MITO, Mineyo
HAMADA, Arisa
SENOO, Misato
HIRAKAWA, Tetsu
NAKANO, Kikuo
subject
arterial stiffness
chronic obstructive pulmonary disease
lung diffusing capacity
cardioankle vascular index
abstract
Previous studies have demonstrated that arterial stiffness is independently associated with the severity of pulmonary emphysema observed on computed tomography (CT) in patients with chronic obstructive pulmonary disease (COPD). An inverse correlation exists between emphysema severity on CT image and lung diffusing capacity; however, the relationship between lung diffusing capacity and arterial stiffness in patients with COPD remains unclear. We retrospectively analyzed the data of 30 patients with COPD. Percent predicted diffusing capacity of the lung for carbon monoxide divided by alveolar volume (%DLco/VA) was used as an index of lung diffusing capacity. We used the Goddard score as an index of the severity of pulmonary emphysema on CT image and cardio-ankle vascular index (CAVI) as an index of arterial stiffness. CAVI was inversely correlated with %DLco/VA (r = −0.539, p = 0.002) but not correlated with Goddard score (rs = 0.236, p = 0.209). None of the other respiratory parameters investigated, including forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity ratio, and percent predicted FEV1, were correlated with CAVI. In multiple regression analysis, systolic blood pressure (β = 0.404, p = 0.006), %DLco/VA (β = −0.379, p = 0.012), and modified Borg scale score for dyspnea (β = 0.304, p = 0.033) were significant predictors of CAVI. Lung diffusing capacity is a significant independent predictor of arterial stiffness in patients with COPD. The evaluation of %DLco/VA in patients with COPD might be useful for predicting high CAVI and the development of cardiovascular disease in the future.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 70
issue
Issue 1
start page
7
end page
15
date of issued
2021-06-30
publisher
Hiroshima University Medical Press
issn
0018-2052
2433-7668
ncid
publisher doi
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2021 Hiroshima University Medical Press
relation url
department
Graduate School of Biomedical & Health Sciences
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