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ID 39615
file
title alternative
哺乳動物の精子形成における睾丸性ヒアルロニダーゼの役割
creator
Yamane, Jinshin
Kashiwabara, Takao
NDC
Zoology
abstract
1. Although the chemical action of testicular hyaluronidase peculiar to the mammal has been fairly well defined by the elaboration of numerous biochemists, its physiological significance cannot be seen as fully established.
2. The generalized concept postulated with the idea of "spreading factor", that its dispersal activity on the follicular cell-mass enclosing the ovum is a necesssary antecedent to ensure the fertilization, seems to be unjustifiable because of lack of such a cell-mass at ovulation in a number of mammalian species.
3. The object of this paper is to present the evidence of intracelullar activity of the testicular hyaluronidase indispensable for normal spermatogenesis.
4. A highly purified bovine testicular hyaluronidase was repeatedly injected to the male mouse and rabbit.
5. A remarkable disorganization was observed for a while in spermatogenic epithelia.
6. Lack of meiotic divisions or meiotic irregularities in the spermatocytes and pycnosis or nuclear fragmentation resulting further in debris formation, karyorrhexis and karyolysis of the spermatids were prevailing phenomena.
7. As a consequence, a striking decrease in number of intratubular spermatozoa and a partial infertility occurred.
8. In the sera of rabbits subjected to the injections of hyaluronidase, an antibody which inhibits the dispersal action of homologous enzyme on the follicular cell-mass of rabbit ovum was definitely demonstrated.
9. It follows, therefore, that the disintegration of spermatogenic epithelia particularly meiotic irregularities are results of inhibitory action of antibody which is formed agaist the testicular hyaluronidase administered.
10. The mechanism involved in such a relationship between spermatogenic abnormalities and antigenic effects of hyaluronidase was discussed.
journal title
Journal of the Faculty of Fisheries and Animal Husbandry
volume
Volume 1
issue
Issue 3
start page
321
end page
336
date of issued
1957-12-25
publisher
広島大学水畜産学部
issn
0440-8756
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biosphere Science
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