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ID 31333
file
title alternative
Effects of exercise intensity on salivary level of secretory immunoglobulin A in patients with chronic obstructive pulmonary disease
creator
Taito, Shunsuke
Kawaguchi, Kotaro
Inamizu, Tsutomu
Morita, Naoki
subject
慢性閉塞性肺疾患
分泌型免疫グロブリンA
運動強度
chronic obstructive pulmonary disease
secretory immunoglobulin A
exercise intensity
NDC
Medical sciences
abstract
外来通院中の慢性閉塞性肺疾患(COPD)患者5名を対象に, 運動負荷強度の違いが唾液中分泌型免疫グロブリンA(唾液中SIgA)に与える影響について検討した. 運動負荷は, 漸増シャトルウォーキングテスト(ISWT)を実施し, 最大歩行速度の40%および80%に相当する運動強度を算出し, 20分間のトレッドミル歩行をそれぞれ実施した(40% ISWT, 80% ISWT). 各運動負荷の実施前後に唾液採取を行い, 酵素標識免疫測定法を用いて, 唾液中SIgA濃度を測定し, 唾液中SIgA分泌速度を算出した. その結果, 40% ISWT後には5例中3例において唾液中SIgA分泌速度が低下し, 残りの2例において増加した. 一方, 80% ISWT後には5例中4例において唾液中SIgA分泌速度が低下し, 残りの1例において増加した. 健常者でも免疫機能が低下することが報告されている高強度の運動負荷に加え, COPD患者では低強度の運動負荷後でも免疫機能が低下する可能性が示唆された.
abstract
The present study was designed to examine the effects of exercise intensity on local immunity of the upper respiratory tract. We measured salivary levels of secretory immunoglobulin A (SIgA) in five outpatients with chronic obstructive pulmonary disease (COPD). Maximum walking speed for each subject was determined by incremental shuttle walking test (ISWT). Exercise was 20 min walking on a treadmill at speeds of 40% or 80% of ISWT (40% or 80% ISWT). Saliva samples were collected before and after exercise. Salivary SIgA concentrations were measured by enzyme-linked immunosorbent assay and secretion rates (μg/min) were calculated by multiplying the salivary SIgA concentration by saliva flow rate (ml/min) for each subject. After 40% ISWT, the salivary SIgA secretion rate of three patients decreased but that of the other two increased. After 80% ISWT, the salivary SIgA secretion rate of four patients decreased while that of the remaining one increased. It was suggested that in addition to the decline in local immunity after high intensity exercise like that seen in a normal healthy subject, the local immunity of the upper respiratory tract for COPD patients deceased after even low intensity exercise.
journal title
Journal of health sciences, Hiroshima University
volume
Volume 8
issue
Issue 1・2
start page
27
end page
33
date of issued
2009-12-10
publisher
広島大学保健学出版会
issn
1347-7323
ncid
SelfDOI
language
jpn
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2009 広島大学保健学出版会
department
Graduate School of Health Science
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