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ID 35006
file
creator
Imai, Keisuke
Munehisa, Yumiko
Yoshikuni, Yoshiko
Morita, Tadayuki
Nomura, Hiroaki
Mimaki, Yuichi
subject
Theophylline
Children
Pyrexia
Clearance
NDC
Medical sciences
abstract
Fifty hospitalized children with asthmatic bronchitis and bronchial asthma were treated with a continuous intravenous drip infusion of aminophylline. To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a pyrexia group (≥ 38°C) and a non-pyrexia group (< 38°C). Theophylline clearance was 0.064 ± 0.017 liters/kg/hr in the non-pyrexia group and 0.049 ± 0.010 liters/kg/hr in the pyrexia group. Theophylline clearance in the non-pyrexia and pyrexia groups was 0.044 ± 0.007 liters/kg/hr and 0.030 ± 0.009 liters/kg/hr (≤ 6 months), 0.071 ± 0.011 liters/kg/hr and 0.047 ± 0.008 liters/kg/hr (6 to ≤ 12 months), 0.084 ± 0.012 liters/kg/hr and 0.055 ± 0.006 liters/ kg/hr (1 to ≤ 2 years), and 0.065 ± 0.007 liters/kg/hr and 0.051 ± 0.001 liters/kg/hr (2 to ≤ 3 years), respectively. In all age groups, theophylline clearance of the pyrexia group was significantly less than that of the non-pyrexia group (p < 0.01), showing that there was a significant pharmacokinetic difference in theophylline clearance between the groups. Multivariate statistical analysis showed that theophylline clearance was affected by pyrexia and age. This study showed that the presence of pyrexia decreases theophylline clearance, and that it affects theophylline clearance in an age-dependent manner. Based on the results of this study, dosages should be designed based on the clearance at the time of pyrexia.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 61
issue
Issue 1
start page
15
end page
18
date of issued
2012-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
(c) Hiroshima University Medical Press.
department
Graduate School of Biomedical Science
University Medical Hospital
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