このエントリーをはてなブックマークに追加
ID 37676
file
creator
Yamashita, Keisuke
subject
Ureter
Epithelium
Cell kinetics
Mice
NDC
Medical sciences
abstract
The present study aimed at clarifying the cell kinetics of the mouse ureteral epithelium by focusing on vesicle maturation in the cells and labeling with bromodeoxyuridine (BrdU). Electron microscopically, superficial cells were characterized by concave plaques in the apical plasma membrane and numerous fusiform vesicles in the cytoplasm. Intermediate cells were laden with ellipsoid vesicles, and basal cells had a few or no round vesicles. From the difference in number and form of vesicles among the three types of cells, it can be inferred that intermediate cells are immature in comparison with superficial cells, and likewise basal cells in comparison with intermediate cells. When BrdU was injected intraperitoneally once a day for seven days, most BrdU-labeled cells were located in the basal layer. Twelve days after the last injection, BrdU was detected in the intermediate or superficial layer in addition to the basal layer. These findings suggest that the basal cell is a progenitor cell giving rise to daughter cells that migrate upward to replace intermediate and superficial cells.
description
This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by Health Science Research Grants for Research on Environmental Health from the Ministry of Health, Labour and Welfare of Japan.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 51
issue
Issue 2
start page
41
end page
48
date of issued
2002-06
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧