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ID 37720
file
creator
Yamashita, Shoko
Nagai, Nobutaka
Oshita, Takafumi
Sakata, Kenichiro
Murakami, Tomohiro
Shigemasa, Kazushi
Tanioka, Yoshihide
Inai, Kouki
Ohama, Koso
subject
Adenoma malignum
Clinicocytopathological study
Immunohistochemical study
HIK 1083
NDC
Medical sciences
abstract
Adenoma malign um is a rare type of very highly differentiated adenocarcinoma of the uterine cervix, and is quite difficult to diagnose because there are few findings definitely suggesting malignancy on cytologic or histologic examination. We recently encountered four patients with adenoma malignum and reviewed their clinicocytopathological and immunohistochemical findings. The most characteristic symptom was a watery discharge and an enlarged cervix was palpable, while multiple cystic lesions (MCL) were observed by transvaginal and abdominal ultrasonography, CT or MRI. On cytodiagnosis, the cervical gland cells formed large sheets or showed a palisading arrangement. Slightly enlarged nuclei and yellowish-orange staining of the cytoplasmic mucus were the characteristic findings. On histological examination, many cervical glands of different sizes were present and extended deep into the muscle layer, while branching or papillary growth into the lumen was also observed.  

On immunohistochemical study, HIK1083, a monoclonal antibody for gastric gland mucous cell mucin, was found to be positive in 3 of 4 cases, and this was fairly useful in the diagnosis of adenoma malignum.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 49
issue
Issue 4
start page
167
end page
173
date of issued
2000-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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