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ID 37816
file
creator
Furue, Toshiaki
Yakehiro, Masuhide
Seyama, Issei
subject
Na channel
L-type Ca channel
Lipid-soluble toxins
Myocardium
NDC
Medical sciences
abstract
The effect of grayanotoxin I (GTX I), veratridine and aconitine with either an external or internal concentration of 100 μM on L-type calcium (Ca) channels was studied using the whole cell patch clamp and internal dialysis methods. The experimental conditions for the modification of sodium (Na) channels induced by the internal application of these toxins was determined by showing sustained inward currents with depolarizing repetitive pulses. These toxins failed to generate any change in Ca channels under the same experimental protocol as for Na channels. However, external application of these toxins caused a moderate block of the Ca channels without changing the kinetics.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 46
issue
Issue 1
start page
43
end page
50
date of issued
1997-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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