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ID 37867
file
creator
Igawa, Mikio
Urakami, Shinji
Shirakawa, Hiroki
Shiina, Hiroaki
Ishibe, Tomoyuki
Usui, Tsuguru
Moriyama, Hiroyuki
subject
Mapping
Bladder cancer
Cell proliferation
NDC
Medical sciences
abstract
Transitional cell carcinoma of the urinary bladder is a multifocal disease and the whole bladder mucosa is more or less involved in the neoplastic process. A mapping study of 5 cystectomy specimens was performed, and cell proliferation was evaluated immunohistochemically using anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody. A correlation between the pathological findings and the rates of PCNA-positive cells was observed in both the tumor and the surrounding mucosa in 4 of the 5 cases. The rates of PCNA-positive cells increased in areas with normal mucosa adjacent to those with dysplasia or transitional cell carcinoma, and in areas with normal mucosa or dysplasia adjacent to those with carcinoma in situ or transitional cell carcinoma in 2 cases. These features may indicate that a field change observed in the mapping study of a bladder with cancer is a manifestation of a stepwise progression of the mucosal disease.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 44
issue
Issue 4
start page
93
end page
97
date of issued
1995-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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