Identification of 5' Regulatory Elements of the PDGF-A Chain Gene, and Interaction with Single-stranded DNA Binding Protein
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00037898
ID | 37898 |
file | |
creator |
Takimoto, Yasuo
Kuramoto, Atsushi
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subject | PDGF-A
5' regulatory elements
single-stranded DNA binding protein
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NDC |
Medical sciences
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abstract | The expression of platelet-derived growth factor (PDGF) is controlled in a very complicated manner. To clarify the mechanism of regulation of the PDGF-A chain gene, deletion analysis of the 5'-flanking region was performed. We identified a positive regulatory element 25 base pairs (bp) upstream of TATAA, a negative element 135 bp upstream, a positive element 223 bp upstream and a negative element further upstream. These regulatory sites of the PDGF-A chain gene may be involved in tissue specificity, developmental regulation, and transformation. In addition, our analysis suggested the presence of a strand non-specific single-stranded DNA binding nuclear protein in the positive regulatory element 25 bp upstream of TATAA.
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journal title |
Hiroshima Journal of Medical Sciences
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volume | Volume 43
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issue | Issue 4
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start page | 179
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end page | 184
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date of issued | 1994-12
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publisher | Hiroshima University Medical Press
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issn | 0018-2052
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ncid | |
language |
eng
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nii type |
Departmental Bulletin Paper
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HU type |
Departmental Bulletin Papers
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DCMI type | text
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format | application/pdf
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text version | publisher
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department |
Research Institute for Radiation Biology and Medicine
Graduate School of Biomedical Science
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他の一覧 |