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ID 38005
file
creator
Hossain, Md. Delawar
Fujii, Kohyu
Yuge, Osafumi
Kawahara, Michio
Morio, Michio
subject
Anesthetics, volatile: sevoflurane.
Biotransformation: fluorometabolites.
Ions, fluoride: excretion.
NDC
Medical sciences
abstract
Serum concentrations and urinary excretion of inorganic fluoride (fluoride ion), a metabolite of sevofluorane, were measured by an ion-chromatographic analyzer after inhalation of three different concentrations of sevoflurane in adult, male Japanese white rabbits weighing 2.6-3.6 kg. Sevoflurane was administered at concentrations of 0% (control), 1%, 2% and 3% (Groups I, II, III and IV, respectively) through a sevoflurane vaporizer for 2 hr under controled ventilation. Blood and urine samples were collected during and after termination of sevoflurane inhalation at scheduled time intervals for 24 hr. The total volume of urine, the urinary pH and the osmolality of serum and urine were not significantly different among any of the groups. Osmolality of the serum and urine was within normal range in all groups of animals. The mean serum peak values of fluoride ion were 0.7±0.5, 22.8±8.7, 31.8±11.0 and 41.5±13.2 μM (mean± SD) in groups I, II, III and IV, respectively. Peak values were recorded within 15 min after the termination of inhalation. The cumulative amounts of fluoride ion excreted in urine in 24 hr were calculated to be 5.0±1.6, 26.1±6.7, 41.4±11.3 and 64.3±18.0 μmol (mean±SD) in groups I, II, III and IV, respectively. Regression analysis revealed significant correlations between the formation and excretion of fluoride ion, and the dose of sevoflurane (r=0.85, p<0.05 and r=0.89, p<0.05, respectively). The authors conclude that the formation and excretion of fluoride ion after sevoflurane anesthesia is dependent on the dose of the drug. This study also concludes that 1-3% of sevoflurane for 2 hr of inhalation is unlikely to produce renal dysfunction.
description
This study was supported in part by a Research Grant from the Japanese Ministry of Education, Science and Culture.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 40
issue
Issue 1
start page
1
end page
7
date of issued
1991-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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