このエントリーをはてなブックマークに追加
ID 38127
file
creator
Kato, Tadahiro
subject
Dopamine
Serotonin
Veratrine
Neuroleptic malignant syndmme
NDC
Medical sciences
abstract
Stereotaxic microinjection of veratrine (50 μg in 1 μl of saline) into the preoptic anterior hypothalamus of rats which were intraperitoneally pretreated with haloperidol (1 mg/kg), significantly elevated body temperature (1.4 °C above normal body temperature) and produced abnormal behaviors. This microinjection also facilitated turnover of dopamine and serotonin in the regions of the thalamus and hypothalamus. Hyperthermia induced by haloperidol plus veratrine was significantly inhibited by systemic administration of serotonin antagonists (cyproheptadine 10 mg/kg, ritanserin 3 mg/kg). These findings suggest that hyperthermia in neuroleptic malignant syndrome is due to the dominant effect of serotonin in the thermoregulatory center either by blocking the dopamine receptor or by enhancing the serotonin secretion.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 38
issue
Issue 4
start page
173
end page
181
date of issued
1989-12
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧