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ID 47056
file
848265.pdf 7.28 MB
creator
Zhao, Juanjuan
Matsumoto, Jumpei
Li, Ruixi
Ishii, Yoko
Sasahara, Masakiyo
Peng, Yuwen
Ono, Taketoshi
Nishijo, Hisao
NDC
Medical sciences
abstract
The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and β subunit of receptors of platelet-derived growth factor (PDGFR-β) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR-β-knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR-β KO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR-β KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice. These findings suggest that PDGFR-β plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.
description
This work was supported partly by JSPS Asian Core Program, and the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (B) (25290005).
journal title
BioMed Research International
volume
Volume 2013
start page
848265
date of issued
2013-11
publisher
Hindawi Publishing Corporation
issn
2314-6133
2314-6141
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright © 2013 Juanjuan Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
relation url
department
Graduate School of Biomedical & Health Sciences