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ID 25658
file
creator
Totland, Geir K.
Grotmo, Sindre
Morita, Yuseku
Nishioka, Toyohiro
subject
Striped jack
Atlantic halibut
Fish nodavirus
Pathogenicity
Virulence
Host specificity
Immunohistochemistry
NDC
Zoology
abstract
The present study shows that differences in pathogenicity exist among fish nodavirus strains. In challenge trials, a Japanese strain (SJ93Nag) was highly virulent to larvae of the striped jack Pseudocaranx dentex but replication was not detected in larvae of Atlantic halibut Hippoglossus hippoglossus at 6°C. Conversely, a Norwegian nodavirus strain (AH95NorA) that was highly virulent to the Atlantic halibut larvae did not replicate in striped jack larvae at 20°C. Occurrence of the disease viral encephalopathy and retinopathy (VER) and cumulative mortality were significantly different in the 2 species when challenged with the 2 nodavirus strains. The presence of nodavirus in nervous tissue was monitored by immunohistochemical methods. Our results support the view that the genetic diversity among nodavirus strains reflects the existence of different viral phenotypes which may be adapted to infect different host species and/or for replicating at different temperatures. Fish nodaviruses represent surveyable pathogens well suited for studying the relation between viral genotypic and phenotypic properties such as host specificity, temperature optima, neuroinvasiveness and neurovirulence.
journal title
Diseases of Aquatic Organisms
volume
Volume 38
issue
Issue 3
start page
167
end page
175
date of issued
1999-11-30
publisher
Inter-Research
issn
0177-5103
1616-1580
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 1999 Inter-Research.
relation url
department
Graduate School of Biosphere Science