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ID 34824
file
creator
Fujihara, Junko
Takeshita, Haruo
Kimura, Kaori
Kataoka, Kaori
Soejima, Mikiko
Koda, Yoshiro
Yuasa, Isao
Iida, Reiko
Ueki, Misuzu
Kominato, Yoshihiko
Yasuda, Toshihiro
subject
Ethnic difference
Height
IGF1
LHX3-QSOX2
Personal identification
SNPs
NDC
Medical sciences
abstract
Adult height is a highly heritable trait involving multiple genes. Recent genome-wide association studies have identified that SNP rs12338076 in the LHX3-QSOX2 locus, and rs1457595 and rs17032362 in the IGF1 locus are associated with human height in the Japanese population (Okada et al. (2010)[9]). We performed a replication study to examine the associations between these three SNPs and adult height in the Japanese population based on autopsy cases. However, it was not possible to confirm that all these SNPs influenced adult height in the study population. We first conducted a wide-ranging survey of these three SNPs in the above genes using nine different populations including Asians, Africans and Caucasians, and demonstrated that the genotypes of rs12338076 and rs17032362 were distributed in an ethnicity-dependent manner; even within Asian populations, the genotype distributions of the SNPs differed widely. Although there are differences in height distribution between different populations, possibly due to genetic factors and/or gene-environmental interactions, the contradictory results of the association study and ethnic differences in genotype distribution allow us to assume that these height-related SNPs in the genes may contribute to adult height to a slight extent, at least in the Japanese population. It is anticipated that the present information will be useful for developing a reliable tool for personal identification through elucidation of the genetic basis of human height.
journal title
Legal Medicine
volume
Volume 14
issue
Issue 4
start page
205
end page
208
date of issued
2012
publisher
Elsevier Ireland Ltd
issn
1344-6223
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
(c) 2012 Elsevier Ireland Ltd. All rights reserved.
relation url
department
Graduate School of Biomedical Science