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ID 28880
file
creator
Matsuura, Kanji
Kashiwado, Kozo
Fujita, Kazushi
Akagi, Yukio
Yuki, Shintarou
Murakami, Yuji
Wadasaki, Koichi
Monzen, Yoshio
Ito, Atsushi
Kagemoto, Masayuki
Mori, Masaki
Ito, Katsuhide
subject
Involved-field radiation therapy (IFRT)
Elective nodal irradiation (ENI)
Three-dimensional conformal radiation therapy (3DCRT)
Non-small-cell lung cancer (NSCLC)
Carboplatin (CBDCA)
Paclitaxel (PTX)
NDC
Medical sciences
abstract
We aimed to evaluate the feasibility and efficacy of hypofractionated involved-field radiation therapy (IFRT) omitting elective nodal irradiation (ENI) with concurrent chemotherapy for locally advanced non-small-cell lung cancer (NSCLC). Between July 2004 and July 2006, ten patients with locally advanced NSCLC were included in this study. One had stage IIIA and 9 had stage IIIB disease. The treatment consisted of IFRT in fractions of 2.5 Gy and weekly carboplatin (CBDCA)/paclitaxel (PTX). Hypofractionated IFRT with a median total dose of 65 Gy with median percent total lung volume exceeding 20 Gy (V20) of 20.2%, and a median of five courses of chemotherapy with weekly CBDCA (area under the curve, 1.5-2.0)/PTX (30-35 mg/m(2)) were given to all patients. The median survival time and the 1-, 2-, and 3-year overall survival rates were 29.5 months and 90.0%, 58.3%, and 43.8%, respectively. No elective nodal failure was encountered during the median follow up of 18.2 months. No acute or late toxicities of grade 3 or worse were observed. No in-field recurrence occurred in the group with a total dose of 67.5 Gy or more, but there was such recurrence in 83.3% of those in the group with less than 67.5 Gy. Hypofractionated IFRT with weekly CBDCA/PTX was a feasible treatment regimen. Hypofractionated IFRT with a total dose of 67.5 Gy or more could be a promising modality to improve the treatment results in patients with locally advanced NSCLC.
journal title
International Journal of Clinical Oncology
volume
Volume 14
issue
Issue 5
start page
408
end page
415
date of issued
2009-10-24
publisher
Springer Tokyo
issn
1341-9625
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2009 Springer
relation
The original publication is available at www.springerlink.com
relation url
department
Graduate School of Biomedical Science