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ID 17067
file
creator
Tang, He-Bin
subject
Olopatadine
Substance P release
Dorsal root ganglion
Bradykinin
Capsaicin
Transient receptor potential vanilloid 1
NDC
Medical sciences
abstract
Olopatadine, a second-generation antihistamine, has recently been suggested to have an inhibitory effect on the tachykinin release from guinea-pig tracheobronchial smooth muscle preparation. In the present study, using a highly sensitive radioimmunoassay for substance P, we observed that olopatadine attenuated the enhancement of capsaicin-induced substance P release by bradykinin with an IC50 value of 12.5 μM, without any inhibitory effect on the substance P release induced by capsaicin, potassium or bradykinin from cultured dorsal root ganglion neurons. These data suggest that olopatadine may therefore be involved in the bradykinin-induced sensitization of the transient receptor potential vanilloid 1 in cultured dorsal root ganglion neurons.
journal title
European Journal of Pharmacology
volume
Volume 552
issue
Issue 1-3
start page
78
end page
82
date of issued
2006-12-15
publisher
Elsevier
issn
0014-2999
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2006 Elsevier Ltd.
relation is version of URL
http://dx.doi.org/10.1016/j.ejphar.2006.09.016
department
Graduate School of Biomedical Science