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ID 17055
file
creator
Fujiwara, Yasushi
subject
motor evoked potentials
central motor conduction time
spinal cord evoked potentials
cervical myelopathy
transcranial magnetic stimulation
NDC
Medical sciences
abstract
Objective: The objective of this study was to analyze corticospinal function in patients with compressive cervical myelopathy and to elucidate the mechanism underlying its prolonged central motor conduction time (CMCT). Methods: Motor evoked potentials following transcranial magnetic stimulation (TMS) and peripheral conduction time in the ulnar and tibial nerves following electrical stimulation were measured from the abductor digiti minimi (ADM) and abductor hallucis (AH) muscles in 24 patients with compressive cervical myelopathy and used to calculate CMCT. Spinal cord evoked potentials (SCEPs) following transcranial electric stimulation were recorded intraoperatively from the C2-3 to C6-7 intervertebral levels. Correlations between prolonged CMCT and SCEP values were then estimated. Results: The shorter/longer CMCT between the patients' right and left ADM and AH were 8.5 ± 2.9/11.5 ± 3.3 and 16.2 ± 3.1/18.4 ± 3.3 ms, respectively (mean ± SD). The SCEPs amplitude at C6-7, compared to C2-3, was 25.7 ± 21.0 %.0 The attenuation of SCEP amplitude, but not latency, at C6-7 correlated significantly with CMCT prolongation. Conclusions: Our data support the view that CMCT prolongation is primarily due to corticospinal conduction block, rather than conduction delay. Significance: Insight was provided into the mechanism of corticospinal dysfunction in compressive cervical myelopathy.
journal title
Clinical Neurophysiology
volume
Volume 117
issue
Issue 3
start page
623
end page
627
date of issued
2006-03
publisher
Elsevier
issn
1388-2457
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2006 Elsevier Ltd.
relation is version of URL
http://dx.doi.org/10.1016/j.clinph.2005.11.010
department
Graduate School of Biomedical Science