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ID 49162
file
creator
Nishiyama, Yoshiko
Yamamura, Takanao
Takebayashi, Yoshitake
Tanaka, Keisuke
Shimoda, Haruki
Kawakami, Norito
Furukawa, Toshi A
subject
adolescence
subthreshold depression
major depressive episode
university student
cohort study
abstract
Purpose: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year.
Patients and methods: One hundred and seventy-two participants <20 years of age (mean age: 18.32 years, standard deviation: 0.50), who did not meet the full criteria for an MDE, were selected from 2,494 screened freshmen based on the Beck Depression Inventory, 2nd edition (BDI-II). We conducted a cohort study of three groups (low-, middle-, and high-symptom groups) divided based on BDI-II scores, over a 1 year period with the use of bimonthly assessments. Temporal changes of depressive symptoms were analyzed using linear mixed modeling and growth mixture modeling.
Results: First, we found that late adolescents with subthreshold depression (high depressive symptoms) were split between the increasing and decreasing depressive symptoms groups, whereas the majority of the less-symptoms group remained stable during 1 year. Second, in comparison with late adolescents with less depressive symptoms, those with subthreshold depression had an elevated risk of later depression.
Conclusion: Some late adolescents with subthreshold depression had increased depressive symptoms and developed an MDE during 1 year. Therefore, it is necessary for us to rigorously assess the changes in subthreshold depressive symptoms over time in late adolescents.
description
This study was supported (in part) by JSPS KAKENHI Grant Number JP16H06395, JP16H06399 and Grant-in-Aid for Scientific Research on Innovative Areas (23118004; Adolescent Mind & Self-Regulation) from the Ministry of Education, Culture, Sports, Science and Technology.
journal title
Neuropsychiatric Disease and Treatment
volume
Volume 13
start page
25
end page
33
date of issued
2016-12-22
publisher
Dove Medical Press
issn
1176-6328
1178-2021
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
© 2017 Jinnin et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
relation url
department
Graduate School of Integrated Arts and Sciences
Graduate School of Biomedical & Health Sciences
Health Service Center