Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages
CAJ_12-10_1069.pdf 1.33 MB
Anionic and neutral fullerene derivatives were dissolved in water by β-(1,3-1,6)-D-glucan (β-1,3-glucan) as a solubilizing agent. In the water-solubilized complexes, the concentrations of fullerene derivatives were ca. 0.30 mM and the average particle sizes were ca. 90 nm. The β-1,3-glucan complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (λ > 610 nm) when compared with that of other β-1,3-glucan-complexed fullerene derivatives. This result suggests that carboxylic acid moieties in the complex enhance the binding affinity with β-1,3-glucan-receptors on the surface of macrophages when β-1,3-glucan is recognized. In contrast, all β-1,3-glucan complexed fullerene derivatives showed no photodynamic activity toward HeLa cells under the same conditions.
This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
Chemistry - An Asian Journal
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This is the peer reviewed version of the following article: A. Ikeda, T. Iizuka, N. Maekubo, K. Nobusawa, K. Sugikawa, K. Koumoto, T. Suzuki, T. Nagasaki, M. Akiyama, Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages, Chem.-Asian J., 12, 1069–1074, 2017, which has been published in final form at https://doi.org/10.1002/asia.201700182. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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Graduate School of Engineering