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ID 51079
file
creator
Takahashi, Sigeo
Kubo, Katsumaro
Imano, Nobuki
Nishibuchi, Ikuno
Kenjo, Masahiro
subject
Stereotactic body radiotherapy (SBRT)
hepatocellular carcinoma (HCC)
resection
radiofrequency ablation (RFA)
transarterial chemoembolization (TACE)
abstract
Introduction: According to several guidelines, stereotactic body radiation therapy (SBRT) for early hepatocellular carcinoma (HCC) can be considered an alternative to other modalities, such as resection, radiofrequency ablation (RFA), and transarterial chemoembolization (TACE), or when these therapies have failed or are contraindicated. This article reviews the current status of SBRT for the treatment of HCC.

Areas covered: From the results of many retrospective reports, SBRT is a promising modality with an excellent local control of almost 90% at 2–3 years and acceptable toxicities. Currently there are no randomized trials to compare SBRT and other modalities, such as resection, RFA, and TACE, but many retrospective reports and propensity score matching have shown that SBRT is comparable to the different modalities. Repeated SBRT for intra-hepatic recurrent HCC also resulted in high local control with safety and satisfactory overall survival, which were comparable to those of other curative local treatments.

Expert opinion: Despite the good results of SBRT, the conclusions of the comparisons of SBRT and other modalities are still controversial. Further studies, including randomized phase III studies to define that patients are more suitable for each curative local treatment, are needed.
journal title
Expert Review of Gastroenterology and Hepatology
volume
Volume 14
issue
Issue 4
start page
271
end page
279
date of issued
2020-03-30
publisher
Taylor and Francis
issn
1747-4124
1747-4132
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Gastroenterology and Hepatology on 30 Mar 2020, available online: http://www.tandfonline.com/10.1080/17474124.2020.1744434.
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
relation url
department
University Medical Hospital
Graduate School of Biomedical & Health Sciences