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ID 30863
file
creator
Sakamoto, Naoya
Anami, Katsuhiro
Naito, Yutaka
Aoyagi, Kazuhiko
Sasaki, Hiroki
subject
Gastric cancer
Intestinal phenotype
Connexin 30
Microarray
NDC
Medical sciences
abstract
Aims: The mucin phenotype is associated with clinicopathological findings and tumorigenesis in gastric cancer (GC). The aim was to search for a novel marker regulating the intestinal phenotype of GC. Methods and Results: We performed microarray analyses, and GJB6 (encoding connexin 30) was identified as a gene associated with the intestinal phenotype. Immunostaining of connexin 30 in 169 GC cases revealed that 47 (28%) cases were positive for connexin 30, while connexin 30 was negative in nonneoplastic gastric tissue. Connexin 30-negative GC cases showed more advanced T grade, N grade, and tumor stage than connexin 30-positive GC cases. Six (13%) GC cases positive for connexin 30 were histologically of the differentiated type. In addition, the expression of gastric and intestinal phenotypes of GC was examined by immunostaining for MUC5AC, MUC6, MUC2, and CD10. Connexin 30 expression occurred more frequently in the intestinal phenotype (48%) than in other phenotypes (21%) of GC. Conclusion: These results indicate that the expression of connexin 30 is a novel differentiation marker mediating the biological behavior of intestinal phenotype GC.
journal title
Pathobiology
volume
Volume 77
issue
Issue 5
start page
241
end page
248
date of issued
2010
publisher
Karger
issn
1015-2008
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2010 S. Karger AG, Basel
relation url
department
Graduate School of Biomedical Science