Vanadate inhibits endoplasmic reticulum stress responses <Short communication>
EurJPharm_594_44.pdf 208 KB
endoplasmic reticulum stress
vanadate; glucose-regulated protein 78 (GRP78)
CCAAT/enhancer-binding protein homologous protein (CHOP)
The disruption of endoplasmic reticulum function leads to an accumulation of unfolded proteins, which results in endoplasmic reticulum stress. In the present study, we investigated the effect of vanadate on such stress. Endoplasmic reticulum stress increased glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) expressions in glial cell cultures. We found that vanadate inhibited the endoplasmic reticulum stress-induced increase in GRP78 and CHOP expressions at both mRNA and protein levels. Thus, these results suggest that vanadate modulates endoplasmic reticulum stress responses and that novel vanadate-responsive protein(s) might be involved in these processes.
European Journal of Pharmacology
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Elsevier Science BV
Crown Copyright (c) 2008 Published by Elsevier B.V. All rights reserved.
Graduate School of Biomedical Science