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ID 25589
file
creator
Shiraishi, Jun-ichi
Yanagita, Kouichi
Fujita, Masanori
subject
POMC
food intake
insulin
central nervous system
chick
melanocortins
NDC
Zoology
abstract
Growing evidence suggests that insulin interacts with both orexigenic and anorexigenic peptides in the brain for the control of feeding behavior in mammals. However, the action of central insulin in chicks has not yet been identified. In the present study, we investigated the effects of central injection of insulin on feeding behavior in chicks. Intracerebroventricular (ICV) administration of insulin, at doses that do not influence peripheral glucose levels, significantly inhibited food intake in chicks. Central injection of insulin in chicks significantly increased expression of pro-opiomelanocortin (POMC) mRNA, and decreased that of neuropeptide Y (NPY) mRNA. Finally, co-injection of the melanocortin antagonist (SHU9119 or HS014) prevented the reduction in food intake caused by ICV administration of insulin. These data suggest that insulin functions in chicks as an appetite-suppressive peptide in the central nervous system, and that the central melanocortin system mediates this anorexic effect of insulin, as in mammals.
journal title
Domestic Animal Endocrinology
volume
Volume 34
issue
Issue 3
start page
227
end page
229
date of issued
2008-04
publisher
Elsevier Inc
issn
0739-7240
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2007 Elsevier Inc
relation is version of URL
http://dx.doi.org/10.1016/j.domaniend.2007.05.002
department
Graduate School of Biosphere Science