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ID 25587
file
creator
Yanagita, Kouichi
Shiraishi, Jun-ichi
Fujita, Masanori
subject
β-Endorphin
N-terminal fragment
feeding behavior
central nervous system
chick
NDC
Zoology
abstract
It is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4 nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0 nmol) also increased food intake at 30 min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
journal title
Neuroscience Letters
volume
Volume 442
issue
Issue 2
start page
140
end page
142
date of issued
2008-09
publisher
Elsevier Ireland Ltd
issn
0304-3940
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2008 Elsevier Ireland Ltd
relation is version of URL
http://dx.doi.org/10.1016/j.neulet.2008.07.018
department
Graduate School of Biosphere Science