Biomolecule detection based on Si single-electron transistors for highly sensitive integrated sensors on a single chip
ApplPhysLett_100_023704.pdf 504 KB
Biomolecule detection was achieved using a Si single-electron transistor (SET) for highly-sensitive detection. A multiple-island channel-structure was used for the SET to enable room-temperature operation and to increase sensitivity. Coulomb oscillation shifted against the gate voltage due to biotin-streptavidin binding. Coulomb oscillation has a possibility to increase transconductance (gm), and a higher gm leads to greater sensitivity to a charged target. Since a Si structure is important for integrating label-free-biomolecule and/or ion sensors into large-scale-integrated circuits, a Si SET with multiple islands should enable the integration of a sensor system on a single chip for multiplexed detections and simultaneous diagnoses.
Applied Physics Letters
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American Institute of Physics
(c) 2012 American Institute of Physics
Research Center for Nanodevices and Systems