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ID 46494
file
creator
Sukhdorj, Elbegzaya
Nakamura, Ryuji
Yanabe, Kensuke
Hirano, Hiroki
Hirano, Harutoyo
subject
Photoplethysmogram
Anesthesia
Nociceptive reflex
NDC
Medical sciences
abstract
A specific and reliable method for monitoring analgesia during general anesthesia is urgently required. Previously, we introduced a method that indicates arterial mechanical properties for estimating arterial wall stiffness (K). However, whether the response of K actually indicates changes in remifentanil target concentrations under continuous surgical stress, is unclear. Thus, we aimed to evaluate how K responds to different remifentanil target concentrations.
This prospective study enrolled 30 patients who underwent laparoscopic colectomy. The patients received 3 different effect-site concentrations (2, 4, and 6 ng/ml) of remifentanil 3 times during the study period. The K values at 4-ng/ml administration were used as control values (Kcontrol). K values at 6-ng/ml administration (K6ng) and those at 2-ng/ml administration (K2ng) were normalized by dividing them by the control values. The results showed that K responded to the changes in remifentanil concentration, significantly decreasing at 6-ng/ml remifentanil effect-site concentration and increasing at 2-ng/ml concentration. The stress response at low analgesia was higher than that at high analgesia, and, as predicted, normalized K2ng was significantly greater than normalized K6ng. In conclusion, we found that K is a sensitive stress response monitor and dynamically responds to changes in remifentanil concentration in invasive stimulation during laparoscopic colectomy.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 67
issue
Issue 3
start page
55
end page
61
date of issued
2018-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2018 Hiroshima University Medical Press
department
Graduate School of Biomedical & Health Sciences
University Medical Hospital
Graduate School of Engineering
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