Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of A. actinomycetemcomitans
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00017082
ID | 17082 |
file | |
creator |
Nishikubo, Shuichi
Ikura, Masae
Fujiwara, Tamaki
Komatsuzawa, Hitoshi
|
NDC |
Medical sciences
|
abstract | Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers varying from 102 to 108 U/mg. SNP analysis of the Cdt gene in clinical isolates identified a variation of single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating chromatin degrading activity of CdtB.
|
journal title |
Infection and Immunity
|
volume | Volume 74
|
issue | Issue 12
|
start page | 7014
|
end page | 7020
|
date of issued | 2006-12
|
publisher | American Society for Microbiology
|
issn | 0019-9567
|
ncid | |
publisher doi | |
pubmed id | |
language |
eng
|
nii type |
Journal Article
|
HU type |
Journal Articles
|
DCMI type | text
|
format | application/pdf
|
text version | author
|
rights | Copyright (c) 2006 American Society for Microbiology.
|
relation is version of URL | http://dx.doi.org/10.1128/IAI.02063-05
|
department |
Graduate School of Biomedical Science
|