Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of A. actinomycetemcomitans
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00017082
| ID | 17082 |
| file | |
| creator |
Nishikubo, Shuichi
Ikura, Masae
Fujiwara, Tamaki
Komatsuzawa, Hitoshi
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| NDC |
Medical sciences
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| abstract | Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers varying from 102 to 108 U/mg. SNP analysis of the Cdt gene in clinical isolates identified a variation of single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating chromatin degrading activity of CdtB.
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| journal title |
Infection and Immunity
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| volume | Volume 74
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| issue | Issue 12
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| start page | 7014
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| end page | 7020
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| date of issued | 2006-12
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| publisher | American Society for Microbiology
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| issn | 0019-9567
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| ncid | |
| publisher doi | |
| pubmed id | |
| language |
eng
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| nii type |
Journal Article
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| HU type |
Journal Articles
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| DCMI type | text
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| format | application/pdf
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| text version | author
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| rights | Copyright (c) 2006 American Society for Microbiology.
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| relation is version of URL | http://dx.doi.org/10.1128/IAI.02063-05
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| department |
Graduate School of Biomedical Science
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