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ID 33095
file
title alternative
Behavioral study of time perception with nigrostriatal lesion in rats. <Articles>
creator
Ujita, Asami
subject
interval timing
peak procedure
6-OHDA
rat
NDC
Psychology
abstract
We studied the effects of an injection of 6-hydroxydopamine (6-OHDA) into the substantianigra of rats on the performance of timing behavior by using a peak interval (PI) procedure. Rats were trained on a PI 30-s procedure for 30 sessions. Then, subjects were divided into three groups: lesion (n=6), operational sham lesion (n=3) and intact (n=3). After 6-OHDA treatment, subjects were retrained on the PI 30-s procedure for 15 sessions and were checked for their timing behavior. Results indicated that sham and intact groups did not change the performance of timing between pre- and post- operation treatment. In the lesion group, a behavioral change occurred shortly after lesion treatment. They showed a dull curved peak in PI 30-s and peak time showed an in accuracy of 30-s. However, the lesion group recovered their performance following repeated training for 15 sessions. It is suggested that we should further investigate the durability of the 6-OHDA, as well as conduct histological analysis of the striatum, which is the dopamine (DA) projection ahead of the substantianigra. Such investigations would enable the identification of possible relationships between the function of substantianigra and time perception.
journal title
Bulletin of the Graduate School of Integrated Arts and Sciences, Hiroshima University. I, Studies in human sciences
volume
Volume 6
start page
1
end page
11
date of issued
2011-12-31
publisher
広島大学大学院総合科学研究科
issn
1881-7688
ncid
SelfDOI
language
jpn
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2011 by Graduate School of Integrated Arts and Sciences, Hiroshima University All rights reserved
department
Graduate School of Integrated Arts and Sciences
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