Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00024603
ID | 24603 |
file | |
creator |
Sakamoto, Naoya
Aoyagi, Kazuhiro
Sasaki, Hiroki
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subject | hepatoid adenocarcinoma
hepatocellular carcinoma
PLUNC
microarray
SAGE
gastric cancer
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NDC |
Medical sciences
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abstract | Gastric cancer is one of the most common malignancies worldwide. In this study, we screened for genes upregulated in gastric cancer by comparing gene expression profiles from serial analysis of gene expression and microarray and identified the palate, lung, and nasal epithelium carcinoma-associated protein (PLUNC) gene. Immunostaining for PLUNC in 140 gastric cancer cases revealed strong and extensive staining of PLUNC in hepatoid adenocarcinoma of the stomach, whereas 727777677340f conventional gastric cancer cases showed focal immunostaining of PLUNC. Gastric hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphologic similarities to hepatocellular carcinoma. To investigate the utility of PLUNC immunostaining in the diagnosis of gastric hepatoid adenocarcinoma, six cases of gastric hepatoid adenocarcinoma (six primary tumors and two associated liver metastases) were studied further. PLUNC staining was observed in all six primary hepatoid adenocarcinomas. PLUNC staining was observed in both the hepatoid adenocarcinoma and tubular/papillary adenocarcinoma components of primary tumors, although PLUNC staining was preferentially localized in tubular/papillary adenocarcinoma components. Staining of PLUNC was also detected in both liver metastases. PLUNC staining was not observed in 52 cases of primary hepatocellular carcinoma or in normal adult or fetal liver. These results indicate that PLUNC is a novel marker that distinguishes gastric hepatoid adenocarcinoma from primary hepatocellular carcinoma.
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journal title |
Modern Pathology
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volume | Volume 21
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issue | Issue 4
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start page | 464
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end page | 475
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date of issued | 2008-04
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publisher | Nature Publishing Group
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issn | 0893-3952
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ncid | |
publisher doi | |
pubmed id | |
language |
eng
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nii type |
Journal Article
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HU type |
Journal Articles
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DCMI type | text
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format | application/pdf
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text version | author
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rights | Copyright (c) 2008 USCAP, Inc
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relation is version of URL | http://dx.doi.org/10.1038/modpathol.3801050
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department |
Graduate School of Biomedical Science
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