Resilience means resistance to high-risk environmental factors or overcoming stress and adversity. We interpreted resilience as a defense against the onset of the comorbidity of autism spectrum disorder (ASD), or recovery to adaptation, and examined it. The subjects were 74 university students with characteristics of ASD (43 men and 31 women) who visited our center from April 2015 to October 2017. We examined such factors as the subjects’ comorbidities, presence or absence at school due to truancy or other short absences, troubles experienced, and resilience factors, which included support by parents, teachers, and friends, acceptance of disabilities, having a hobby, and the desire for a relationship. Students who did not have the support of friends experienced significantly more troubles, and students who were serious or who did not have a hobby had significantly more school absences. Key points in dealing with such students appear to be to support reinforcement of resilience, to arrange a support environment (especially friends), and to recommend hobbies, club activities, and part-time jobs.