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ID 49997
file
creator
SUEDA, Taijiro
MAEDA, Yoshiyuki
HAMANAKA, Yoshiharu
ISHIHARA, Hiroshi
MATSUURA, Yuichiro
KAJIHARA, Hiroki
subject
Myocardial protection
Cardiac transplantation
Bretschneider's solution
Heterotopic cardiac transplantation
NDC
Medical sciences
abstract
Myocardial preservation by Bretschneider's solution (BR solution, Group I) with an intracellular like electrolyte and histidine buffer action was compared with EC-Bi solution (Group II) which has an extracellular like electrolyte and bicarbonate buffer action in the mongrel dogs. The PH and PCO2 of the effluent from the coronary sinus were maintained during myocardial ischemia for 3 hr but the lactate rose gradually in group I. The oxygen and lactate up-take ratio of the myocardium after re-perfusion was satisfactory and LV max dp/dt was also maintained at a high level in group I. Morphologically, myelin figure and mitochondrial deformation were more found in group II on electron microscopy.
A donor heart preserved for 3 hr in cold BR solution was transplanted in the left thoracic cavity in four mongrel dogs by the technique of the heterotopic cardiac transplantation. Resuscitation of cardiac pulsation was smooth and maintenance of the systemic circulation after transplantation was possible in every case. From these findings, it might be concluded that myocardial preservation using cold BR solution was useful for cardiac transplantation.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 36
issue
Issue 3
start page
309
end page
313
date of issued
1987-09
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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