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ID 49940
file
creator
NAKAMURA, Koji
NAKAMOTO, Takahisa
MORIYAMA, Hiroyuki
MIZUTAN, Masami
SAGAMI, Koji
NIHIRA, Hiromi
ITO, Akihiro
subject
3β-hydroxysteroid dehydrogenase
Hyperprolactinemia
17β-estradiol
Rat testis
NDC
Medical sciences
abstract
The effects of hyperprolactinemia on the activity of 3β-hydroxysteroid dehydrogenase (3β-HSD) in rat testis were studied during excessive 17β-estradiol (E2) administration. Without E2 treatment, 3β-HSD activity did not change significantly in moderate hyperprolactinemic rats (756 ± 179 ng/ml). However, this enzyme activity was significantly decreased in marked hyperprolactinemic rats (3612 ± 1090 ng/ml) compared to that in control rats (45.4 ± 6.2 ng/ml). Under the excessive E2 administration, this enzyme activity was insignificantly decreased in slight hyperprolactinemic rats (218 ± 42 ng/ml1 and inhibited in moderate hyperprolactinemic rats (566 ± 77 ng/ml) as refer to control level.
It may be concluded that inhibition of 3β-HSD activity in testis due to the excess administration of estrogen is promoted by the transplantation of MtT/F84 which produces prolactin at the limited level.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 4
start page
339
end page
342
date of issued
1986-12
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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