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ID 49920
file
creator
YAMANE, Takashi
NAKABAYASHI, Hidekazu
ITO, Shiro
SUMII, Hiroshi
KAWAI, Akira
subject
Tissue culture
Thermochemotherapy
Human osteosarcoma cell
Cis-dichlorodiammineplatinum (II)
NDC
Medical sciences
abstract
Human osteosarcoma cells (HuO-3Nl cells) and fibroblastic cells with normal human karyotype (HuO-3 cells) were derived from a patient with osteosarcoma. HuO-3N1 cells were more sensitive to heat treatment than HuO-3 cells. The combination of heat and cis-dichlorodiammineplatinum (II) (CDDP) exerted synergistic cytotoxity on HuO-3N1 cells, and was much less cytotoxic to HuO-3 cells than to HuO-3Nl cells. Therefore, thermochemotherapy with CDDP may be useful for treatment of human osteosarcoma.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 3
start page
191
end page
195
date of issued
1986-09
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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