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ID 49910
file
creator
YAMAKIDO, Michio
YANAGIDA, Jitsuro
ISHIOKA, Shinichi
MATSUZAKA, Shigeru
HOZAWA, Soichiro
TAKAISHI, Masatoshi
INAMIZU, Tsutomu
AKIYAMA, Mitoshi
NISHIMOTO, Yukio
subject
Poison gas workers
Serum factors
Mitogenic response of lymphocytes
NDC
Medical sciences
abstract
The relation of depressed immune function to carcinogenesis has been estimated in the living body. The authors have measured the immunological parameters in former poison gas workers, a group having a high risk of carcinogenesis, for comparison with age matched normal controls and the following results were obtained.
1) With regard to serum factors, no significant difference could be demonstrated between normal controls and poison gas workers in such immunoglobulins as IgG, IgA, and IgM, in acute phase reactants such as α1-AT, α1-AG, α2-HS and C3 and in such tumor markers as CEA, ferritin, and β2-microglobulin. Furthermore, no difference could be observed in the positive rate of immune complex and in complement activity.
2) No difference could be observed between the two groups with regard to tuberculin skin reaction and number of lymphocytes, but the longer the duration of work at the poison gas factory, the more significant was the increase in those who showed negative tuberculin skin reaction.
3) In comparison with normal controls, mitogenic response to PHA showed a significant decrease in poison gas workers, but no significant difference could be seen in mitogenic response to Con A and PPD and in mixed lymphocyte reaction.
4) No significant difference could be demonstrated between the two groups in the inhibitory effects of serum on mitogenic response to PHA and Con A and on mixed lymphocyte reaction.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 2
start page
117
end page
126
date of issued
1986-06
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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