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ID 49902
file
creator
NAKANISHI, Masanao
subject
Mycobacterium lepraemurium
M. Intracellulare
Vaccination
NDC
Medical sciences
abstract
Since Mycobacterium lepraemurium (Mlm) is closely related to Mycobacterium intracellulare, with respect to its antigenicity, attenuated Mlm obtained by passages on 1% Ogawa egg medium was examined for possible effects as a vaccine against M. intracelJulare infection. Four weeks after subcutaneous injection of Mlm (1.4 x 107 bacilli), mice were infected intravenously with 2.4 x 107 organisms per mouse of M. intracellulare. During the first 12 weeks, no difference was noted in the rate of progression of M. intracellulare infection between mice given or not given Mlm-vaccine, when severity of the infection was measured on the basis of the number of viable M. intracellulare in the lungs and spleen. Therefore, Mlm-vaccine is probably not efficacious in protecting mice against M. intracellulare infection.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 1
start page
67
end page
69
date of issued
1986-03
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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