このエントリーをはてなブックマークに追加
ID 49893
file
creator
OKIDA, Motoichi
KIKUCHI, Hirosato
FUJII, Kohyu
subject
Biotransformation
Concentration-dependence
Halothane
NDC
Medical sciences
abstract
Effect of end-expiratory halothane concentration on its aerobic and anaerobic metabolism was studied in 20 male rabbits.
Biliary excretion of trifluoroacetic acid (TF AA), an aerobic metabolite of halothane, and the pulmonary excretion of CF2CHCl (CDFF) and CF3CH2Cl (CTFE), anaerobic metabolites of halothane, were measured simultaneously during 5 hr of inhalation at various concentrations of halothane (0.02-1.5%).
The total amount of biliary TF AA excreted for 5 hr remained unchanged (38.4μmol- 44.lμmol) at each concentration except 0.02%. However, the total amount of CDFE and CTFE excreted for 5 hr increased in a concentration-dependent manner up to 0.5% end-expiratory halothane, and remained unchanged (47.2μmol-64.7μmol) at more than 0.5%. Total biliary excretion of TF AA reached its maximum at a 0.05%.
These results suggest that the primary route of halothane metabolism at a subanesthetic concentration is the aerobic pathway which produces TF AA. However, at anesthetic concentration exceeding 0.5%, the anaerobic route which produces volatile CDFE and CTFE plays a role also as an aerobic route.
description
This study was supported in part by Science Research Grants from the Ministry of Education, Science and Culture of Japan
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 1
start page
15
end page
20
date of issued
1986-03
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧



Last 12 months's access : ? times
Last 12 months's DL: ? times


This month's access: ? times
This month's DL: ? times